The sensitivity of this technique may be improved by utilising fluorophores that selectively bind to cancer cells; emerging evidence from preclinical studies suggest this may be achieved by conjugation of ICG with metal compound nanoparticles, such as ferritin [60] or copper sulphate [69], or by utilising dyes conjugated with antibodies that recognise cancer-associated receptors, such as EGFR and c-Met [70, 71]. Here, EGFR is linked to cancer.