YTHDF1 and neoplasm: To further elucidate whether the upregulation of p27 is the key factor inhibiting tumor cell proliferation following YTHDF1 knockdown, we conducted a subsequent knockdown of p27 in indicated cells already subjected to YTHDF1 knockdown and found that p27 knockdown countered the effect of YTHDF1 (Figs. 3A–B, S3A).