In YTHDF1 knockdown tumor cells, only RNF7 (RING Finger protein 7), also known as SAG (Sensitive to Apoptosis Gene), a crucial subunit of the RBX/ROC RING of E3 ubiquitin ligase essential for cancer cell growth [25–27], was significantly reduced compared to control cells. The gene discussed is YTHDF1; the disease is cancer.