To validate the critical role of YTHDF1/RNF7/p27 in prostate cancer, we initially assessed RNF7 expression in a prostate cancer tissue microarray and observed a positive correlation between RNF7 and YTHDF1 proteins, without detecting significant change in RNF7 mRNAs (Fig. 4A–C). Here, RNF7 is linked to Familial prostate cancer.