Liver fibrosis was significantly attenuated after Havcr2 haploinsufficiency in 5-week MCD-fed mice as assessed by Sirius red staining and α-SMA IHC staining and as indicated by the expression levels of fibrosis-related markers, but the expression of proinflammatory cytokines was not significantly changed (Fig. 1H, I, S2C–E, K, L). This evidence concerns the gene ACTA1 and Hepatic fibrosis.