CTLA4 and metabolic dysfunction-associated steatohepatitis: Then, we found that Havcr2 (encoding TIM3) was dramatically upregulated in fibrotic liver tissues compared with other checkpoint markers (PD1, PD-L1, LAG3, CTLA4, and TIGIT) in these liver tissues, suggesting that TIM3 may be involved in NASH fibrosis (Fig. 1B).