HAVCR2 and metabolic dysfunction-associated steatotic liver disease: To further explore the role of TIM3 in macrophages at different stages of NAFLD, we investigated the effect of Havcr2 haploinsufficiency on both 2 weeks of the early stage of NAFLD and 5 weeks of a later stage of NAFLD in Havcr2fl/+; Lyz2-cre or Havcr2 KD mice (Fig. 1G, S2A, B, H).