According to these criteria, a diagnosis of TRAPS is highly suspected with a heterozygous pathogenic (or likely pathogenic) variant in TNFRSF1A identified by genetic testing in the context of at least 1 of the following clinical features: a flare lasting at least 7 days, myalgia, migratory rash, periorbital edema, or a suggestive family history. Here, TNFRSF1A is linked to TNF receptor 1-associated periodic fever syndrome.