TNFRSF1A and pericarditis: In an observational study of 131 patients, TNFRSF1A gene mutations were found in about 6% of patients with RP and were strongly correlated with a positive family history of pericarditis and/or recurrent fever syndrome, RP after the first year from the initial episode, failure to respond to colchicine, and the need for immunosuppressive agents.7