These proteins were associated with increases in liver X receptor (LXR)/ retinoid X receptor (RXR) activation that can regulate inflammation and lipid metabolism,39,40 extracellular matrix organization that is associated with the development of hepatic fibrosis,41 and DHCR24 signaling that can signal via LXR and protein kinase B (PKB/AKT)42 and, when inhibited, can ameliorate MASLD40 (Figure 2D). Here, AKT1 is linked to Hepatic fibrosis.