ROCK2 and neoplasm: Preclinical studies have shown that spinal ROCK2 expression or ROCK2 immunoreactivity is elevated in various neuropathic pain models, including partial sciatic nerve injury (SNI) [16], spinal nerve ligation (SNL) [17], tumor cell implantation (TCI) [18], and inflammatory pain induced by formalin [19] or lipopolysaccharide (LPS) [20].