TNF and neoplasm: The human mature NK cell population is subdivided according to the expression of the surface markers CD56 and CD16: the cytotoxic population CD56dim / CD16pos (CD56dim), which accounts for 90% of circulating NK cells; and the regulatory NK cell subsetCD56bright / CD16neg (CD56bright), which produces a large number of pro-inflammatory cytokines, such as Interferon IFN-γ and TNF-α [62], For instance, IFN-γ coordinates enhanced anti-tumor responses by regulating dendritic cell antigen presentation and triggering CTL activation [63].