Since KCNJ13 mutations have not been linked with nanophthalmia, rather leading to more severe retinal disorders (Leber congenital amaurosis and snowflake vitreoretinal degeneration), the potential role of the MFRP–KCNJ13 interaction in ocular development and homeostasis remains unresolved and also requires further investigation. Here, MFRP is linked to vitreoretinal degeneration.