MYBPC3 and Ventricular arrhythmia: For example, patients with a P/LP variant in the sarcomere gene MYBPC3, such as one case in our study who had a clinical diagnosis of HCM pre-mortem, are at particularly high risk for ventricular arrhythmias.46 At present, the incorporation of genetic data into individualized HCM SCD risk estimation and the need for primary prevention ICD remains controversial.