For example, patients with a P/LP variant in the sarcomere gene MYBPC3, such as one case in our study who had a clinical diagnosis of HCM pre-mortem, are at particularly high risk for ventricular arrhythmias.46 At present, the incorporation of genetic data into individualized HCM SCD risk estimation and the need for primary prevention ICD remains controversial. This evidence concerns the gene MYBPC3 and Schnyder corneal dystrophy.