PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Insulin resistance and certain genetic variants—specifically in the patatin-like phospholipase domain containing 3 (PNPLA3), lipid transporter located on endoplasmic reticulum (TM6SF2), and transmembrane 6 superfamily member 2 genes—have been implicated in the pathogenesis of NAFLD [1–5].