After 6.4 ± 0.6 months, when average low‐density lipoprotein cholesterol levels had been lowered from 3.58 ± 0.11 mM to 2.1 ± 0.06 mM, blood levels of CLL cells and beta‐2‐microglobulin (β2M) increased significantly, accompanied by significant decreases in platelets. Here, B2M is linked to B-cell chronic lymphocytic leukemia.