Similar nanoparticles have employed differing ROS-responsive components,including the selenium–selenium (-SeSe-) element.104 Wu et al. synthesized a ROS-responsive nanoparticleassembled using polylactic acid-glycolic acid (PLGA)-SeSe-mPEG, loadedwith dexamethasone (DEX) and chondrogenic differentiation factor cartilage-derivedmorphogenetic protein-1 (CDMP-1) for the treatment of osteoarthritis.104 Exposure to 500 μM H2O2in vitro prompted a DEX release rate higherthan 60% and a CDMP-1 release rate of 37.7% due to -SeSe- cleavage. Here, GDF5 is linked to osteoarthritis.