Among these, caspase 3/7 death proteases are indispensable and are frequently activated during drug treatment, driving cells toward programmed cell death.[33, 34] To investigate whether caspase 3/7 activation contributes to GW‐CpG‐sHDL‐induced cell death in mouse and human glioblastoma cells, we performed a luminescence‐based caspase‐3/7 activation assay on mouse glioblastoma, human glioblastoma, and normal human astrocytes (Figure S4C, Supporting Information). The gene discussed is CASP3; the disease is glioblastoma.