Prior work has demonstrated that radiation therapy can increase the number of MDSCs present in the tumor microenvironment by augmenting the levels of CCL2, CCL5, and CSF‐1.[38] More MDSCs lead to higher levels of nitric oxide, TGF‐b, Arg1, and IL‐10, ultimately suppressing the activity of CD4+ and CD8+ T‐cells. This evidence concerns the gene TGFB1 and neoplasm.