CD8A and neoplasm: Cholesterol accumulation in the tumor microenvironment has been shown to induce CD8+ T‐cell exhaustion by upregulating the expression of inhibitory receptors such as PD‐1 and 2B4.[10] Importantly, previous studies have shown that treatment of T‐cells with B‐cyclodextrin (which binds and removes cholesterol from cells) can reverse T‐cell exhaustion.