TNF and neoplasm: While macrophages are not direct targets of CAR T‐cells, their depletion likely results from releasing cytotoxic cytokines, such as TNF, from CAR T‐cells within the tumor microenvironment.[57] This finding underscores the complex interplay between immune and nonimmune cells and highlights the broader effects of CAR T‐cell activity, which is partially reflected in the IAC model.