IL‐6, known for its dual role in promoting inflammation and immune regulation, can support tumor progression by driving STAT3 activation and immune evasion mechanisms while contributing to CAR T‐cell exhaustion.[54] IL‐8, a potent chemokine, is associated with the recruitment of immunosuppressive myeloid cells, particularly tumor‐associated macrophages and neutrophils, which can counteract CAR T‐cell efficacy by creating an immunosuppressive microenvironment.[55, 56] Our study further revealed the depletion of CD68‐positive macrophages in the presence of anti‐ROR1 CAR T‐cells. This evidence concerns the gene ROR1 and neoplasm.