SPHK1 and infection: Not only did the RNAseq experiment confirm our RT-qPCR results (i.e., upregulation of SPHK1 and SPHK2 but also SGPL1 and SGPP1) (Fig. 4a; Data S1), but also revealed regulation of additional SL metabolism genes upon infection (Fig. 4; Fig. S2), in addition to a vast array of inflammatory mediators.