ACKR2 and neoplasm: Nevertheless, it is important to note that using ACKR2 inhibitors in clinical settings poses complex and context-dependent effects within the TME, as ACKR2 has been shown to play both tumor-suppressing and tumor-promoting roles.27 Its tumor-suppressive effect is primarily attributed to its ability to limit inflammation by scavenging pro-inflammatory chemokines, thereby reducing tumor-promoting chronic inflammation.