In melanoma, T cell infiltration is strongly associated with a distinct chemokine gene signature that includes CCL2, CCL3, CCL4, CCL5, CXCL9 and CXCL10.5 This signature underscores the complexity of the chemokine network, which collectively shapes the immune landscape within the tumor microenvironment (TME) by promoting lymphocyte infiltration. The gene discussed is CCL4; the disease is neoplasm.