NPPB and pulmonary hypertension: Pulmonary hypertension (PH), defined by a resting mean pulmonary artery pressure >20 mm Hg, is associated with reduced life expectancy.1,2 Patients present a diagnostic challenge,3 as their symptoms, such as shortness of breath, are not specific to an elevated pulmonary artery pressure, causing delays in diagnosis.4 Noninvasive investigations, such as transthoracic echocardiography and plasma brain natriuretic peptide (BNP) measurements, are used to identify patients for the definitive diagnostic test, right heart catheterization.5,6