However, for distinguishing PAH from other forms of PH, the miRNA signature significantly outperformed NT-proBNP (balanced accuracy of 0.58 versus 0.47, sensitivity of 0.74 versus 0.57, specificity of 0.43 versus 0.38, McNemar P=0.017, Table 3). This evidence concerns the gene NPPB and pulmonary arterial hypertension.