NT-proBNP performed well at distinguishing PH (area under the curve [AUC]=0.78) and PAH (AUC=0.79) from DC but was unable to differentiate PAH, PH-LHD, PH-Lung, or CTEPH (AUC=0.49, 0.63, 0.47, 0.42, respectively) from other forms of PH, or PAH from CTEPH (AUC=0.55; Figure 2B). This evidence concerns the gene NPPB and pulmonary arterial hypertension.