NPPB and pulmonary arterial hypertension: Similarly, there was a significant improvement in model performance with the inclusion of NT-proBNP, age, and sex for the WSPH subgroup signatures to identify PAH (balanced accuracy=0.58, sensitivity=0.70, specificity=0.45), PH-LHD (balanced accuracy=0.61, sensitivity=0.62, specificity=0.61), PH-Lung (balanced accuracy=0.56, sensitivity=0.72, specificity=0.39), CTEPH (balanced accuracy=0.62, sensitivity=0.50, specificity=0.74) from all other forms of PH there was a significant improvement compared with the miRNA panel alone (Table 3; Figure S4).