BRAF and non-Hodgkin lymphoma: BRAF affects cell division, differentiation, and secretion by regulating the MAPK/ERK signaling pathway.20 Since its discovery in 2002, BRAF mutations have been reported in melanoma, non-Hodgkin lymphoma, colorectal cancer, thyroid cancer, and other cancer types.23,24 These mutations are classified into types I to III based on their location and functional changes, with type I mutation, V600E, being the most frequent.