ACAD8 and colorectal carcinoma: By analyzing the GDSC database on classic chemotherapy drugs for CRC, we found that high ACAD8 levels were associated with lower IC50 values for 5-Fluorouracil, Cisplatin, Irinotecan, Gemcitabine, Rapamycin, and Paclitaxel (Figures 7A–F), suggesting that ACAD8 can increase sensitivity to chemotherapy in CRC.