In addition, the elevated level of RNA demethylase ALKBH5 in placental villus tissue of patients with recurrent spontaneous abortion (RSA) may be due to its ability to shorten the half-life of CYR61 mRNA in an m6A dependent manner and reduce the level of total m6A modification, affecting the invasiveness of the trophoblast and leading to miscarriage (47). Here, CCN1 is linked to spontaneous abortion.