In gestational diabetes (GDM), the researchers found that the overall mRNA m6A methylation level in the fetal liver of the mouse was significantly increased by constructing a GDM mouse model, and in vitro experiments revealed that RBM15 mediated m6A modification affected the insulin sensitivity of offspring by regulating the expression of CLDN4, leading to metabolic syndrome (160). Here, CLDN4 is linked to gestational diabetes.