ALKBH5 and Miscarriage: In addition, the elevated level of RNA demethylase ALKBH5 in placental villus tissue of patients with recurrent spontaneous abortion (RSA) may be due to its ability to shorten the half-life of CYR61 mRNA in an m6A dependent manner and reduce the level of total m6A modification, affecting the invasiveness of the trophoblast and leading to miscarriage (47).