Under hypoxic condition, the activation of HIFs and their downstream signaling cascades, such as C-X-C chemokine receptor (CXCR)4, macrophage colony-stimulating factor receptor (M-CSFR) and CD47, modulates tumor-specific immune responses by inducing the production of immunosuppressive cytokines and growth factors, promoting tumor immune evasion and ultimately stimulating tumorigenesis (8, 9). This evidence concerns the gene CXCR4 and neoplasm.