FLG and acrodermatitis enteropathica: Filaggrin (FLG) is crucial for maintaining skin barrier integrity. Research by Brown et al. Identified mutations in the FLG gene as a significant risk factor for developing allergic eczema, particularly in patients of European descent (80). This study linked genetic predisposition to the clinical presentation of atopic dermatitis and highlighted the importance of barrier dysfunction in AE pathogenesis.