SCFAs involved in the physiological activities of the body mainly through three G protein-coupled receptors, GPR41 (FFAR3), GPR43 (FFAR2), and GPR109A, which are variably expressed in different cells, and interfered in the occurrence and development of NAFLD by regulating glucose and lipid metabolism, restoring the intestinal barrier, and improving oxidative stress (Ikeda et al., 2022). This evidence concerns the gene FFAR3 and metabolic dysfunction-associated steatotic liver disease.