However, it can be internalized into endocytic vesicles or imported into the nucleus in response to stimuli such as epidermal growth factor (EGF), wogonoside, the cancer environment or influenza infections (Sun et al., 2002; Zhou et al., 2005; Wyles et al., 2007; Chen et al., 2013; Zhu et al., 2013; Luo, 2018; Huang et al., 2020; Yang et al., 2024). This evidence concerns the gene EGF and cancer.