For example, when stimulated with EGF, PLSCR1 not only directly binds to the promoter of STAT1, but also enhances STAT3’s binding to the STAT1 promoter in breast cancer cells, leading to the transactivation of STAT1 and basal-like breast cancer (BLBC) progression (Huang et al., 2020). The gene discussed is STAT3; the disease is breast carcinoma.