PITX1 and Lewy body dementia: The authors concluded that high amounts of deleted ccf-mtDNA were related to the primary mitochondrial pathophysiological mechanism believed to precede the clinical manifestation of Lewy body disease.17 In our study, the ccf-mtDNA levels did not discriminate NT1 patients with recent onset, close to the active hypocretinergic neuronal loss, from those more chronic.