IL4 and neoplasm: The CAR-T cells exposed to the target produced a significant increase in Th1 cytokine interferon (IFN)-γ, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-2, and tumor necrosis factor (TNF)-α along with a marginal increase in T helper type 2 cytokines like IL-4, IL-5, and IL-10 for the survival, anti-tumor response and other pro-inflammatory functions (Figure 3A).