KLK3 and metastatic prostate carcinoma: As shown in Figure 2, the ROC analysis results for predicting metastatic prostate cancer using individual independent risk factors are as follows: the area under the curve (AUC) for PSA is 0.788 (95% CI: 0.737-0.839, P<0.001), for PDW is 0.608 (95% CI: 0.546-0.670, P<0.001), for Hb is 0.652 (95% CI: 0.592-0.712, P<0.001), for lymphocytes is 0.633 (95% CI: 0.573-0.694, P<0.001), for neutrophils is 0.598 (95% CI: 0.536-0.660, P=0.023), for SII is 0.650 (95% CI: 0.590-0.710, P<0.001), and for the combination of SII and PSA is 0.806 (95% CI: 0.759-0.854, P<0.001).