The results indicated that prostate cancer was associated with BMI (OR: 0.927, 95% CI: 0.867–0.992, p=0.029), SII (OR: 1.001, 95% CI: 1.000–1.001, p=0.025), neutrophils (OR: 1.154, 95% CI: 1.034–1.287, p=0.011), lymphocytes (OR: 0.475, 95% CI: 0.325–0.696, p<0.001), monocytes (OR: 6.488, 95% CI: 2.272–18.530, p<0.001), Hb (OR: 0.970, 95% CI: 0.958–0.983, p<0.001), PDW (OR: 0.874, 95% CI: 0.781–0.978, p=0.019), and PSA (OR: 1.006, 95% CI: 1.004–1.009, p<0.001). This evidence concerns the gene KLK3 and prostate cancer.