The results indicated that prostate cancer was associated with age (OR: 1.074, 95% CI: 1.050–1.097, p < 0.001), BMI (OR: 0.938, 95% CI: 0.886–0.994, p = 0.030), SII (OR: 1.001, 95% CI: 1.000–1.001, p < 0.001), uric acid (OR: 1.002, 95% CI: 1.000–1.004, p = 0.044), lymphocyte count (OR: 0.638, 95% CI: 0.481–0.848, p = 0.002), hemoglobin (OR: 0.982, 95% CI: 0.973–0.992, p < 0.001), and PSA (OR: 1.034, 95% CI: 1.024–1.044, p < 0.001), but not with PDW. This evidence concerns the gene KLK3 and prostate cancer.