HTS also revealed a loss-of-function mutation in NOTCH2. Interestingly, there is evidence in the literature correlating dysregulation of Notch signaling pathway with enhanced immunogenicity and increased infiltration of TILs and CD8+ T cells in different cancer types (47, 48), although its role in the immunogenicity of sarcomas still needs to be investigated. This evidence concerns the gene NOTCH2 and sarcoma.