For instance, PTBP1 promotes glycolysis by regulating the expression of pyruvate kinase M2 (PKM2), a key glycolytic enzyme, while miR-506-3p directly targets PTBP1, downregulating its expression and thereby reducing glycolysis, which restores 5-FU sensitivity in GC cells (148). The gene discussed is PTBP1; the disease is gastric cancer.