In CRC, overexpression of miR-506 in HCT116-OxR cells inhibits the expression of multidrug resistance protein 1 (MDR1)/P-glycoprotein 1 (P-gp) by down-regulating the Wnt/β-catenin pathway, promoting apoptosis in drug-resistant cells and enhancing sensitivity to oxaliplatin (146). This evidence concerns the gene ABCB1 and colorectal carcinoma.