CD36 mediates oxidized LDL uptake-dependent expression of macrophage migration inhibitory factor (MIF) via the lipid peroxidation/p38/CEBPs axis in lpmCAFs, which may recruit CD33+ myeloid-derived suppressor cells (MDSCs) in an MIF- and CD74-dependent manner to promote HCC. This evidence concerns the gene CD33 and hepatocellular carcinoma.