However, despite the ablation of COL-I in either fibroblasts or all liver cells in mouse ICC models using hydrodynamic delivery of oncogenic drivers into hepatocytes reducing stiffness and mechanosensitive signals, loss of COL-I does not prevent tumor growth, implying that COL1-DDR1 signaling is not essential for ICC development (21). The gene discussed is DDR1; the disease is intrahepatic cholangiocarcinoma.