In addition to the classification mentioned above, the CAFs subpopulation in the TME of HCC can be grouped into five common subtypes: vCAF, myCAFs, lipid processing (lp)-myCAFs (lpmCAFs), lpCAFs, and apCAFs by scRNA-seq of human and mouse HCC tumors (Table 1). This evidence concerns the gene HCFC1 and hepatocellular carcinoma.