Specifically, the ESPL1 levels in the LC group were significantly higher than those in the CHB group (P < 0.05), and the ESPL1 levels in the HBV-HCC group were significantly higher than those in the CHB and LC group (P < 0.05), as illustrated in Figure 1. The gene discussed is ESPL1; the disease is laryngotracheoesophageal cleft.