Emerging evidence reveals a positive feedback loop between RhoA/ROCK signaling and Wnt5a pathway in RA-FLSs, where Wnt5a further amplifies RhoA activity through non-canonical pathways, sustaining overexpression of invasion-related genes MMP-3/9 (Rodriguez-Trillo et al., 2020). The gene discussed is WNT5A; the disease is rheumatoid arthritis.