Additionally, CKI has been reported to relieve tumor-associated macrophage-mediated immunosuppression in hepatocellular carcinoma by triggering TNFR1-mediated NF-κB and p38 MAPK signaling, subsequently improving CD8+ T cell cytotoxicity and tumor clearance (Yang et al., 2020). This evidence concerns the gene NFKB1 and neoplasm.