Additionally, as reported (Fei et al., 2024), dimeric PKM2 can act as a coactivator of β-catenin and c-Myc, which are key transcription factors in fibrogenesis (Duspara et al., 2021; Liu et al., 2015), thereby leading to the promotion of liver fibrosis. The gene discussed is MYC; the disease is Hepatic fibrosis.