EPHX2 and Alzheimer disease: 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea (TPPU) is a soluble epoxide hydrolase (sEH) inhibitor that has been reported to prevent glial cell reactivation and alleviate cognitive deficits in the brains of AD mice (Ghosh et al., 2020).