In our previous study, we had shown that SP can improve antioxidant activities and attenuate inflammatory responses through upregulating of Nrf-2/HO-1/NQO1 and downregulating of MAPKs/NF-κB phosphorylation in LPS-stimulated acute lung injury model (Lee et al., 2020). The gene discussed is NFE2L2; the disease is acute lung injury.