– m6A modification regulates mRNA metabolism and gene expression. – IGF2BP proteins are involved in BPD pathogenesis, promoting mRNA stability. – YTHDF2 reduces mRNA stability, affecting hematopoietic stem cell proliferation. – METTL3 enhances hyperoxia-induced pyroptosis in BPD. – Down-regulation of several m6A regulators is observed in BPD cohorts. Here, METTL3 is linked to bronchopulmonary dysplasia.