HDAC3 and bronchopulmonary dysplasia: – Histone acetylation/deacetylation regulates gene transcription. – Changes in histone modification patterns (e.g., hyperacetylation of H2A.Z and H3K9) are linked to BPD. – Histone deacetylase 3 (HDAC3) is pivotal in abnormal pulmonary angiogenesis and alveolar development. – Targeting histone acetylation and chromatin remodeling may offer therapeutic avenues.