In terms of the potential pathogenic mechanism, ox-LDL activates a variety of transcription factors involved in the pathogenesis of COPD, including activator protein 1, NF-κB, signal transducer and activator of transcription (STAT), and hypoxia-inducible factor 1(HIF-1) (34). The gene discussed is SOAT1; the disease is chronic obstructive pulmonary disease.