These findings imply that exogenous PACAP-38 and VIP may act as triggers during the active phase of CH, while their influence appears to be limited during remission, indicating that these neuropeptides may be more involved in the initiation of CH attacks rather than the maintenance of a persistent pathological state, though their effect appears less pronounced compared to CGRP. Here, ADCYAP1 is linked to cyclic hematopoiesis.