ALB and familial pancreatic carcinoma: Macropinocytosis is a lysosomal degradation pathway driven by pancreatic cancer cells expressing KRAS∗, which can provide enough Asp to support pancreatic cancer cell to survive in nutritional constraints by capturing environmental albumin and releasing amino acids within the cells.47, 48, 49 Thus, this nutrient scavenging pathway leads to pancreatic cancer resistance to therapies targeting non-classical metabolic pathways.