Here, pyruvate, as an electron acceptor, is transported into pancreatic cancer cells via monocarboxylate transporter 1 (MCT1) and converted to lactate via lactate dehydrogenase (LDH), which can restore the redox imbalance caused by GOT2 deficiency and reverse the GOT1 pathway to synthesize Asp. The gene discussed is GOT1; the disease is pancreatic neoplasm.