Here, pyruvate, as an electron acceptor, is transported into pancreatic cancer cells via monocarboxylate transporter 1 (MCT1) and converted to lactate via lactate dehydrogenase (LDH), which can restore the redox imbalance caused by GOT2 deficiency and reverse the GOT1 pathway to synthesize Asp. This evidence concerns the gene GOT1 and familial pancreatic carcinoma.