It was ultimately found that, Age (p < 0.001), Residence (p = 0.003), BMI (p < 0.001), Cognitive function (p = 0.003), ADL (p < 0.001), DBP (p = 0.019), Breathing (p < 0.001) and Hb (p < 0.001) were found to be associated with the development of sarcopenia in middle-aged and older adult diabetic mellitus (Table 2). This evidence concerns the gene GSTM1 and diabetes mellitus.