Several heart diseases, including acute myocardial infarction and heart failure, are associated with GJs remodeling (Himelman et al., 2020; Lillo et al., 2023; Sun et al., 2010), mainly characterized by reduced expression, abnormal distribution, and phosphorylation changes of Cx43 (Fontes et al., 2012; Sánchez et al., 2011; Solan & Lampe, 2018). This evidence concerns the gene GJA1 and heart failure.