Although EB1 overexpression reduced ventricular arrhythmias (e.g., ventricular fibrillation) in our experiments, the observed improvement in atrioventricular block could be attributed to enhanced trafficking efficiency of Cx40/Cx45 due to stabilized microtubules or to the regulation of other ion channels. This evidence concerns the gene GJA5 and Ventricular arrhythmia.