MSH2 and colorectal carcinoma: Comparative analysis comparing CRC patients with and without LNM revealed significant differences in various clinical factors (such as histological type, T-stage, M-stage, vascular tumor thrombus, nerve involvement, as well as genetic markers including PMS2, MSH2, KRAS, BRAF, PIK3CA, and counts of leukocytes and neutrophils) between the two groups (P < 0.05, as shown in Table 2).