After the Venn diagram construction between the CRC differential genes via TCGA and the 100 action targets based on network pharmacology, nine overlapped genes ABCB1, ABCG2, BCL2, EGFR, ESR1, ESR2, FGFR2, PIK3CG, and VDR were identified. This evidence concerns the gene VDR and colorectal carcinoma.