NFKBIA and colorectal carcinoma: The study has found that curcumin can reduce the expression levels of NF-κB p65 and the apoptosis inhibitor protein survivin in CRC cells, inhibit the phosphorylation of IκBα, increase the expression level of IκBα protein, and further suppress the activation of the NF-κB pathway, so as to prevent and treat CRC [9].