Subsequently, immunohistochemical examination was carried out to detect the protein level of LGR5 in tumor tissues, as shown in Fig. 10D. Compared with the CRC stem cell group, the protein expression of LGR5 in the cisplatin + stem cell group, the YGS + cisplatin + stem cell group and the Gomisin B + cisplatin + stem cell group was markedly decreased (P < 0.01). The gene discussed is LGR5; the disease is neoplasm.