Mutations in genes related to steroid biosynthesis (such as CYP11A1, CYP17A1, HSD3B2, HSD17B3, and StAR) will lead to androgen synthesis disorders with adrenal insufficiency besides the SRD5A2 gene mutation which results in the insufficient transformation of dihydrotestosterone from testosterone [1]. The gene discussed is HSD3B2; the disease is Adrenal insufficiency.