Patients with 17α-hydroxylase deficiency are characterized by persistent hyperprogestinemia(P range: 3.4-14.04 ng/mL), accompanied by decreases in E2 (< 15pg/ml) and T, and increases in FSH (41.8-148.66IU/L) and LH (14.4-56.58 IU/L).In patients with AIS, E2 levels ranged between 6pg/mL and 65pg/mL; P levels were confirmed with preovulation status; six cases (patients9, 10,11, 15,17 and 19) showed FSH levels greater than 20 IU/L. This evidence concerns the gene BRD2 and androgen insensitivity syndrome.