Mechanistic investigations demonstrated that MST1 deficiency promotes proteolytic activation of SREBP2 (Fig. 2e, g), with transcriptional upregulation of hepatic cholesterol biosynthesis genes (SREBP2, HMGCR, HMGCS1) observed across both standard and WD-fed murine models (Fig. 2f, h). The gene discussed is HMGCR; the disease is Wilson disease.