Pathological analyses of clinical NASH specimens and HFHC-diet murine models reveal cholesterol crystallization within hepatocyte lipid droplets triggers KC activation, instigating pro-inflammatory cytokine cascades (TNF-α, IL- 1β, IL- 6) that drive CCL2/CCR2-mediated neutrophil recruitment and monocyte trafficking [18]. Here, CALCA is linked to metabolic dysfunction-associated steatohepatitis.