Combining urine sediment examination at day 3 (P2 and C2) to uTIMP2*IGFBP7, uKIM-1 and both biomarkers significantly improved their prediction ability to an AUC of to 0.977, 0.951 and 0.979 respectively to predict AKI progression, and to an AUC of 0.807, 0.796 and 0.803 respectively to predict mortality. The gene discussed is IGFBP7; the disease is acute kidney injury.