CD274 and gastric cancer: In agreement with our findings, it has been shown that USP7 is overexpressed in gastric tumors and that USP7 directly binds with PDL-1 to induce its deubiquitination and stabilization [56] and suggested that USP7 abrogation could be used as another approach to downregulate PD-L1 and render gastric cancer cells sensitive to the killing by T cells.