NPPB and obesity due to melanocortin 4 receptor deficiency: In the community cohort, obesity was linked to lower MVX scores (β = -3.30, 95% CI: -5.81 to -0.79, p =.01), while higher NT-proBNP levels were associated with elevated MVX scores (β = 4.14, 95% CI: 3.26 to 5.02, p <.001).