KLK3 and posterior cortical atrophy: Interestingly, when patients with PCa were stratified based on PSA levels (< 4, 4–10 and > 10 ng/ml) according to the guidelines of the National Comprehensive Cancer Network [42, 43], the frequency of ILC2s was significantly increased in patients with PSA values > 10 ng/ml (typically followed by prostate biopsy) compared with HDs with PSA values lower than 4 ng/ml and patients with PCa with PSA values between 4 and 10 ng/ml (Fig. 2E), while no changes were observed for ILC1s and ILCPs (Supplementary Fig. 2F, G).